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Integrative Cancer Therapies, Vol. 5, No. 4,
391-394 (2006)
DOI: 10.1177/1534735406295311
Case Report of a Pituitary Macroadenoma Treated With Artemether
Narendra P. Singh, MBBS, MS
Department of Bioengineering, Box 355061, University of Washington, Seattle, WA 98195. narendra{at}u.washington.edu
Vijay Kumar Panwar, MBBS
Primary Health Center, Jaroda, Muzafarnagar (U.P.), India.
Introduction: This report describes the case of a male patient with pituitary macroadenoma treated with the artemisinin analog artemether. Patient and Methods: A 75 year-old male patient presented with vision, hearing, and locomotion-related problems. Artemether was administered orally to the patient over a period of 12 months. Results: Although the tumor remained consistent in size, CT scan shows a reduction in its density, and clinically, the related symptoms and signs resolved significantly as therapy progressed. Discussion: Overall, the artemether treatment was beneficial in improving the patient's quality of life. Artemether and other artemisinin analogs offer promise for cancer therapy.
Key Words: artemether artemisinin pituitary gland microadenoma cancer apoptosis
References
- Kreutzer J, Fahlbusch R. Diagnosis and treatment of pituitary tumors. Curr Opin Neurol. 2004;17:693-703.[CrossRef][Medline]
[Order article via Infotrieve]
- Johnson MD, Woodburn CJ, Vance ML. Quality of life in patients with a pituitary adenoma. Pituitary. 2003;6:81-87.[CrossRef][Medline]
[Order article via Infotrieve]
- Senovilla L, Nunez L, de Campos JM, et al. Multifunctional cells in human pituitary adenomas: implications for paradoxical secretion and tumorigenesis. J Clin Endocrinol Metab. 2004; 89:4545-4552.[Abstract/Free Full Text]
- Yildiz F, Zorlu F, Erbas F, Atahan L. Radiotherapy in the management of giant pituitary adenomas. Radiother Oncol. 1999; 32:233-237.
- Park P, Chandler WF, Barkan AL, et al. The role of radiation therapy after surgical resection of nonfunctional pituitary macroadenomas. Neurosurg. 2004;55:100-106.[CrossRef][Medline]
[Order article via Infotrieve]
- Dekkers OM, Pereira AM, Roelfsema F, et al. Observation alone after transsphenoidal surgery for non-functioning pituitary macroadenoma. J Clin Endocrinol Metab. 2006;91:1796-1801.[Abstract/Free Full Text]
- Sassolas G, Trouillas J, Treluyer C, Perrin G. Management of nonfunctioning pituitary adenomas. Acta Endocrinol. 1993;129 (Suppl):21-26.
- Zhang F, Gosser DK Jr, Meshnick SR. Hemin-catalyzed decomposition of artemisinin (qinghaosu). Biochem Pharmacol. 1992;43: 1805-1809.[CrossRef][Medline]
[Order article via Infotrieve]
- Lai H, Singh NP. Selective cancer cell cytotoxicity from exposure to dihydroartemisinin and holotransferrin. Cancer Lett. 1995;91:41-46.[CrossRef][Medline]
[Order article via Infotrieve]
- Singh NP, Lai H. Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells. Life Sci. 2001;70:49-56.[CrossRef][Medline]
[Order article via Infotrieve]
- Peys E, Vandenkerckhove J, Van Hemel J, Sas B. Intermediate term toxicity of repeated orally administered doses of the anti malarial beta-artemether in dogs. Exp Toxicol Pathol. 2006;57: 299-304.[CrossRef][Medline]
[Order article via Infotrieve]
- Utzinger J, Xiao SH, N'Goran EK, Bergquist R, Tanner M. The potential of artemether for the control of schistosomiasis. Int J Parasitol. 2001;31:1549-1562.[CrossRef][Medline]
[Order article via Infotrieve]
- Utzinger J, N'Goran E, N'Dri A, Lengeler C, Shuhua X, Tanner M. Oral artemether for prevention of infection: randomised controlled trial. Lancet. 2000;355:1320-1325.[CrossRef][Medline]
[Order article via Infotrieve]
- Xiao S, Yang Y, You Q, et al. Potential long-term toxicity of repeated orally administered doses of artemether in rats. Am J Trop Med Hyg. 2002;66:30-34.[Abstract]
- Murray RA, Maheshwari HG, Russell EJ, Bauman G. Pituitary hypoplasia in patients with a mutation in the growth hormonereleasing hormone receptor gene. Am J Neuroradiol. 2000;21:685-689.[Abstract/Free Full Text]
- Moore JC, Lai H, Li JR, McDougall JA, Singh NP, Chou CK. Oral administration of dihydroartemisinin and ferrous sulfate retarded implanted fibrosarcoma growth in the rat. Cancer Lett. 1995;98:83-87.[Medline]
[Order article via Infotrieve]
- Efferth T, Dunstan H, Sauerbrey A, Miyachi H, Chitambar CR. The anti-malarial artesunate is also active against cancer. Int J Oncol. 2001;18:767-773.[Medline]
[Order article via Infotrieve]
- Singh NP, Verma KB. Case report of a laryngeal squamous cell carcinoma treated with artesunate. Arch Oncol. 2002;10: 279-280.[CrossRef]
- Berger TG, Dieckmann D, Efferth T, et al. Artesunate in the treatment of metastatic uveal melanoma-first experiences. Oncol Rep. 2005;14:1599-1603.[Medline]
[Order article via Infotrieve]
- Singh NP, Lai H. Artemisinin induces apoptosis in human cancer cells. AntiCancer Res. 2004;24:2277-2280.[Medline]
[Order article via Infotrieve]
- Ezzat S, Asa SL, Couldwell WT, et al. The prevalence of pituitary adenomas: a systematic review. Cancer. 2004;101:613-619.[CrossRef][Medline]
[Order article via Infotrieve]
- Feldkamp J, Santen R, Harms E, Aulich A, Modder U, Scherbaum WA. Incidentally discovered pituitary lesions: high frequency of macroadenomas and hormone-secreting adenomasresults of a prospective study. Clin Endocrinol (Oxf). 1999;51:109-113.[CrossRef][Medline]
[Order article via Infotrieve]
- Arita K, Tominaga A, Sugiyama K, et al. Natural course of incidentally found nonfunctioning pituitary adenoma, with special reference to pituitary apoplexy during follow-up examination. J Neurosurg. 2006;104:884-891.[Medline]
[Order article via Infotrieve]
- Kabil MS, Ebv JB, Shahinian HK. Fully endoscopic endonasal vs. transseptal transsphenoidal pituitary surgery. Minim Invasive Neurosurg. 2005;48:348-354.[CrossRef][Medline]
[Order article via Infotrieve]
- Zaugg M, Adaman O, Pescia R, Landolt AM. External irradiation of macroinvasive pituitary adenomas with telecobalt: a retrospective study with long-term follow-up in patients irradiated with doses mostly of between 40-45 Gy. Int J Radiat Oncol Biol Phys. 1995;32:671-680.[CrossRef][Medline]
[Order article via Infotrieve]

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